Integrin beta4 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1305Size: 1 Kit - Containing One 96 Well Plate & All Necessary ReagentsDry Ice: NoHazardous: No
CAT#:0519-EKC1305Size:1 Kit - Containing One 96 Well Plate & All Necessary Reagents
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Description
The Integrin beta4 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Integrin beta4 protein expression profile in cells. The kit can be used for measuring the relative amounts of Integrin beta4 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Integrin beta4.
Synonyms
CD104 antigen; GP150; ITB4; integrin beta-4; integrin beta-4C
Gene Name
ITGB4
UniProt
P16144
Reactivity
Human, Mouse, Rat
Tissue Specificity
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760) .
Molecular Weight
202167 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Integrin beta-4
Subcellular Location
Cell membrane; Single-pass type I membrane protein.Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.

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