Integrin beta4 (Phospho-Tyr1510) Colorimetric Cell-Based ELISA Kit

• Description:

  The Integrin beta4 (Phospho-Tyr1510) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Integrin beta4 (Phospho-Tyr1510) protein expression profile in cells. The kit can be used for measuring the relative amounts of Integrin beta4 (Phospho-Tyr1510) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Integrin beta4 (Phospho-Tyr1510) .

• Synonyms:

  CD104 antigen; GP150; ITB4; integrin beta-4; integrin beta-4C

• Gene Name:

  ITGB4

• UniProt:

  P16144

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760) .

• Molecular Weight:

  202167 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Integrin beta-4

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein.Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.