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FGFR1 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1211Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1211Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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Description
The FGFR1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FGFR1 protein expression profile in cells. The kit can be used for measuring the relative amounts of FGFR1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FGFR1.
Synonyms
BFGF-R; c-fgr; FGFBR; FGFR-1; FGR1; fibroblast growth factor receptor 1; FLG; FLT2; Fms-like tyrosine kinase-2; kinase FGFR1; MFR
Gene Name
FGFR1
UniProt
P11362
Reactivity
Human, Mouse, Rat
Tissue Specificity
Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Molecular Weight
91868 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Fibroblast growth factor receptor 1
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.

UniProtKB · P11362

Fibroblast growth factor receptor 1

FGFR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11362
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FGFR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FGFR-1
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A8K6T9, A8K8V5, C1KBH8, P17049, Q02063, Q02065, Q14306, Q14307, Q53H63, Q59H40, Q5BJG2, Q8N685, Q9UD50, Q9UDF0, Q9UDF1, Q9UDF2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmCytoplasmic vesicleMembraneNucleus

Disease

CraniosynostosisDisease variantDwarfismHoloprosencephalyHypogonadotropic hypogonadismIntellectual disabilityKallmann syndrome

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Molecular function

Heparin-bindingKinaseReceptorTransferaseTyrosine-protein kinase

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Biological process

TranscriptionTranscription regulation

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