Dematin Colorimetric Cell-Based ELISA Kit

The Dematin Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Dematin protein expression profile in cells. The kit can be used for measuring the relative amounts of Dematin in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Dematin.

DEMA; DMT; EPB49; Erythrocyte membrane protein band 4.9

DMTN

Q08495

Human, Mouse

Expressed in platelets (at protein level) . Expressed in heart, brain, lung, skeletal muscle, and kidney.

ELISA

Cell lines

> 5000 cells/well

Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA) . Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

45514 MW

Available

Store at 4°C for up to 6 months.

Dematin