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CREB-BP Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1141Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1141Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CREB-BP Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CREB-BP protein expression profile in cells. The kit can be used for measuring the relative amounts of CREB-BP in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CREB-BP.
Synonyms
CREB-binding protein; CREBBP; CBP
Gene Name
CREBBP
UniProt
Q92793
Reactivity
Human, Mouse
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902) .
Molecular Weight
265351 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
CREB-binding protein
Subcellular Location
Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.

UniProtKB · Q92793

CREB-binding protein

CBP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92793
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CREBBP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DUC9, O00147, Q16376, Q4LE28
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorAcyltransferaseTransferase

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

Biological rhythmsHost-virus interactionTranscriptionTranscription regulation

Domain

BromodomainRepeatZinc-finger

Cellular component

CytoplasmNucleus

Disease

Disease variantIntellectual disability

Ligand

Metal-bindingZinc

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