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CD71/TfR Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1102Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1102Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CD71/TfR Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CD71/TfR protein expression profile in cells. The kit can be used for measuring the relative amounts of CD71/TfR in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CD71/TfR.
Synonyms
CD71 antigen; T9; TFRC; TR; TfR1; Transferrin receptor protein 1; Trfr; p90
Gene Name
TFRC
UniProt
P02786
Reactivity
Human, Mouse
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240) .
Molecular Weight
84871 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Transferrin receptor protein 1
Subcellular Location
Cell membrane; Single-pass type II membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

UniProtKB · P02786

Transferrin receptor protein 1

TFR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02786
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TFRC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TR, TfR, TfR1, Trfr
EC number
—
Processing
—
Secondary accessions
D3DXB0, Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variantMalaria

PTM

Disulfide bondGlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Biological process

EndocytosisHost-virus interaction

Molecular function

Host cell receptor for virus entryReceptorTransducer

Domain

Signal-anchorTransmembraneTransmembrane helix

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