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CaMK4 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1080Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1080Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CaMK4 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CaMK4 protein expression profile in cells. The kit can be used for measuring the relative amounts of CaMK4 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CaMK4.
Synonyms
Calcium/calmodulin-dependent protein kinase type IV catalytic chain; Calspermin; CAM kinase-GR; CaMK IV; CAMK4; CaMKIV; KCC4; kinase CaMK4
Gene Name
CAMK4
UniProt
Q16566
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4 (+) /CD8 (+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2) . Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs) . Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Molecular Weight
51926 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Calcium/calmodulin-dependent protein kinase type IV
Subcellular Location
Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity) .

UniProtKB · Q16566

Calcium/calmodulin-dependent protein kinase type IV

KCC4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16566
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CAMK4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CaMK IV
EC number
2.7.11.17
Processing
—
Secondary accessions
D3DSZ7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInflammatory response

Ligand

ATP-bindingCalciumNucleotide-binding

Molecular function

Calmodulin-bindingKinaseSerine/threonine-protein kinaseTransferase

Cellular component

CytoplasmNucleus

PTM

GlycoproteinPhosphoprotein

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