Anti-Desmoglein-3 (Squamous Cell Marker) DSG3 Monoclonal Antibody

• Background:

  Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3) . This monoclonal antibody is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC) . Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

• Description:

  Boster Bio Anti-Desmoglein-3 (Squamous Cell Marker) DSG3 Monoclonal Antibody (Catalog # M03093) . Tested in WB, IHC applications. This antibody reacts with Human.

• Synonyms:

  Desmoglein-3;130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6; DSG3; CDHF6

• Gene Name:

  DSG3

• UniProt:

  P32926

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human DSG3 extracellular protein fragment

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: DSG3/1535

• Tissue Specificity:

  Epidermis, tongue, tonsil, esophagus and carcinomas.

• Applications:

  WB, IHC

• Field of Research:

  Cadherins, Cell Adhesion, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures

• Purification:

  200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

• Molecular Weight:

  107533 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG1, kappa

• Other Gene Names:

  Desmoglein-3

• Subcellular Location:

  Cell Surface