Anti-CD22/Siglec 2 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-CD22/Siglec 2 Rabbit Monoclonal Antibody catalog # M01572-1. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22; CD22; SIGLEC2

• Gene Name:

  B-cell receptor CD22

• UniProt:

  P20273

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human CD22

• Clonality:

  Monoclonal

• Clone:

  Clone: CBO-3

• Tissue Specificity:

  B-lymphocytes.

• Applications:

  WB

• Field of Research:

  Adaptive Immunity, B Cells, Cancer, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000

• Other Gene Names:

  CD22

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein.

• Protein Name:

  Glycogen synthase kinase-3 beta (gsk3b)