Anti-human CD22/Siglec 2 Monoclonal Antibody FITC Conjugated, Flow Validated

Anti-human CD22/Siglec 2 Monoclonal Antibody FITC Conjugated, Flow Validated

• Background: CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. This gene is mapped to 19q13.2. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. It is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling. This gene can downmodulate signaling through the IgM and IgD B-cell receptors (BCRs), but not through the IgG BCR, because the IgG cytoplasmic tail prevents CD22 phosphorylation and actually enhances IgG-BCR signaling.
• Description: Boster Bio Anti-human CD22/Siglec 2 Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC01572-FITC). Tested in Flow Cytometry application(s). This antibody reacts with Human.
• Synonyms: B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;CD22;SIGLEC2;
• Gene Name: CD22
• UniProt: P20273
• Host: Mouse
• Reactivity: Human
• Immunogen: Human Raji Cells
• Clonality: Monoclonal
• Conjugation: FITC
• Applications: Flow Cytometry
• Sensitivity: 5ul per sample
• Concentration: 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form: Liquid
• Molecular Weight: 95348 MW
• Components: PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide
• Storage Conditions: Store at 2-8°C. Avoid repeated freeze-thaw cycles.
• Fragment: IgG1, k
• Clone ID: Clone: Clone: MYG13