Anti-MLTK MAP3K20 Antibody

• Background:

  Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
  
  Gotoh I., J. Biol. Chem. 276:4276-4286(2001).
  Bloem L.J., J. Mol. Cell. Cardiol. 33:1739-1750(2001).
  Gross E.A., J. Biol. Chem. 277:13873-13882(2002).

• Description:

  Boster Bio Anti-MLTK MAP3K20 Antibody (Catalog # A00902) . Tested in WB, IF applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Mitogen-activated protein kinase kinase kinase MLT;2.7.11.25; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK; ZAK; MLTK; HCCS4

• Gene Name:

  MAP3K20

• UniProt:

  Q9NYL2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from C-terminal of human MLTK.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed. .

• Applications:

  WB, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381) . Involved in limb development (PubMed:26755636) . .

• Molecular Weight:

  91155 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Mitogen-activated protein kinase kinase kinase MLT

• Subcellular Location:

  Cytoplasm . Nucleus . Translocates to the nucleus upon ultraviolet B irradiation. .