Mouse CXCL10/IP-10 ELISA Kit PicoKine®

• Background:

  Chemokine (C-X-C motif) ligand 10 (CXCL10) or IP-10 is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (gamma-IP10 or IP-10) . CXCL10 is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.It is a potent inhibitor of angiogenesis in vivo. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. It is a RAS target gene and is overexpressed in the majority of colorectal cancers.This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.

• Description:

  Mouse CXCL10/IP-10 ELISA Kit PicoKine® (96 Tests) . Quantitate Mouse Cxcl10 in cell culture supernatants, serum and plasma (heparin) . Sensitivity: 1pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  C-X-C motif chemokine 10;10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10; Cxcl10; Crg2, Ifi10, Inp10, Scyb10

• Gene Name:

  C-X-C motif chemokine 10

• UniProt:

  P17515

• Reactivity:

  Mouse

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: E.coli; Immunogen sequence: I22-P98

• Tissue Specificity:

  Expressed in the spleen, thymus, lymph nodes and liver. .

• Applications:

  ELISA

• Field of Research:

  Angiogenesis, Cancer, Chemokines, Immunology, Innate Immunity, Invasion/Microenvironment

• Sample Type:

  Cell culture supernatants, serum and plasma (heparin) .

• Detection Range:

  31.2 pg/ml - 2,000 pg/ml

• Sensitivity:

  <1 pg/ml

• Function:

  In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  CXCL10

• Subcellular Location:

  Secreted.

• Protein Name:

  C-X-C motif chemokine 10