Human CXCL1/Gro Alpha ELISA Kit PicoKine®

• Background:

  Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROalpha, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-alpha) . In humans, this protein is encoded by the CXCL1 gene. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. The mature form of CXCL1 is maximally 73 amino acids long. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.

• Description:

  Human CXCL1/Gro Alpha ELISA Kit PicoKine® (96 Tests) . Quantitate Human CXCL1 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate) . Sensitivity: 1pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha (1-73) ; Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3; GRO-alpha (4-73) ; GRO-alpha (5-73) ; GRO-alpha (6-73) ; CXCL1; GRO, GRO1, GROA, MGSA, SCYB1

• Gene Name:

  Growth-regulated alpha protein

• UniProt:

  P09341

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: E.coli; Immunogen sequence: A35-N107

• Applications:

  ELISA

• Field of Research:

  Cytokines, G Protein Signaling, Immunology, Innate Immunity, Signal Transduction, Signaling Pathway

• Sample Type:

  Cell culture supernatants, serum and plasma (heparin, EDTA, citrate) .

• Detection Range:

  15.6 pg/ml - 1,000 pg/ml

• Sensitivity:

  <1 pg/ml

• Function:

  Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha (4-73), GRO-alpha (5-73) and GRO-alpha (6-73) show a 30-fold higher chemotactic activity. .

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  CXCL1

• Subcellular Location:

  Secreted.

• Sequence Similarities:

  Belongs to the intercrine alpha (chemokine CxC) family.

• Protein Name:

  Growth-regulated alpha protein