SJG-136 intermediate-1

SJG-136 intermediate-1

• CAS Number: 232931-64-5
• UNSPSC Description: SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA[1].
• Target Antigen: ADC Cytotoxin
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/sjg-136-intermediate-1.html
• Purity: 99.95
• Smiles: C=CCOC(N1C2=CC(OCCCOC3=C(OC)C=C(C(N4[C@](CC(C4)=C)([H])[C@@H](N5C(OCC=C)=O)O)=O)C5=C3)=C(OC)C=C2C(N6[C@](CC(C6)=C)([H])[C@@H]1O)=O)=O
• Molecular Weight: 760.79
• References & Citations: [1]S J Gregson, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44(5):737-48.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported