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IMPDH2-IN-2

CAT: 0804-HY-145286-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145286-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki, app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively) . IMPDH2-IN-2 is a potential anti-tuberculosis agent[1].
CAS Number
1434517-02-8
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/impdh2-in-2.html
Purity
99.73
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@H](OC1=CC=CC(Cl)=C1Cl)C(NC2=CC=C(OC(C3=CC=NC=C3)=N4)C4=C2)=O
Molecular Formula
C21H15Cl2N3O3
Molecular Weight
428.27
References & Citations
[1]Chacko S, et al. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64 (24) :18233-18234]. J Med Chem. 2018;61 (11) :4739-4756.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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