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SGK1 Antibody

CAT: 0800-RQ5636Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5636Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene. It is mapped to 6q23.2. This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry: 1-2 µg/mL, Immunofluorescence: 2-4 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
O00141
Host
Rabbit
Reactivity
Human, Monkey
Immunogen
Amino acids AILIAFMKQRRMGLNDFIQKIAN from the human protein were used as the immunogen for the SGK1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, FACS
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the SGK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SGK1 antibody is available for research use only.
Storage Conditions
After reconstitution, the SGK1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SGK1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human HeLa and 2) monkey kidney lysate with SGK1 antibody. Expected molecular weight: 45-60 kDa.

UniProtKB · O00141

Serine/threonine-protein kinase Sgk1

SGK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00141
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SGK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
B7UUP7, B7UUP8, B7UUP9, B7Z5B2, E1P583, Q5TCN2, Q5TCN3, Q5TCN4, Q5VY65, Q9UN56
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

ApoptosisStress response

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmEndoplasmic reticulumMembraneMitochondrionNucleus

PTM

Disulfide bondPhosphoproteinUbl conjugation

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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