Biotin Conjugated Human Complement C5 Recombinant Rabbit Monoclonal Antibody [PSH06-46]

• Description:

  Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

• Product Name Alternative:

  Anaphylatoxin C5a analog antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody C5 antibody C5a anaphylatoxin antibody C5a antibody C5b antibody CO5_HUMAN antibody Complement C5 alpha'' chain antibody Complement C5 antibody Complement component C5 antibody CPAMD4 antibody prepro-C5 antibody

• Abbreviation:

  Complement C5 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 Complement C5 beta chain Complement C5 alpha chain C5a anaphylatoxin Complement C5 alpha' chain C5 CPAMD4

• Swiss Prot:

  P01031 Human

• Cellular Locus:

  Secreted.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within Human Complement C5 19-821.

• Isotype:

  IgG

• Clone:

  PSH06-46

• Conjugation:

  Biotin-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  ELISA (Det)

• Positive Control:

  Recombinant standard Human Complement C5 protein (HA210636).

• Concentration:

  1 mg/mL

• Dilution:

  ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH06-45] to Human Complement C5 antibody (Capture) (HA722682) and recombinant standard Human Complement C5 protein (HA210636) as the standard. The reference range value is 111-9,000pg/mll.

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3