Biotin Conjugated Human Complement C5 Recombinant Rabbit Monoclonal Antibody [PSH06-46]

Biotin Conjugated Human Complement C5 Recombinant Rabbit Monoclonal Antibody [PSH06-46]

• Description: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
• Product Name Alternative: Anaphylatoxin C5a analog antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody C5 antibody C5a anaphylatoxin antibody C5a antibody C5b antibody CO5_HUMAN antibody Complement C5 alpha'' chain antibody Complement C5 antibody Complement component C5 antibody CPAMD4 antibody prepro-C5 antibody
• Abbreviation: Complement C5 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 Complement C5 beta chain Complement C5 alpha chain C5a anaphylatoxin Complement C5 alpha' chain C5 CPAMD4
• CAS Number: 9000-83-3
• Swiss Prot: P01031 Human
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human Complement C5 19-821.
• Isotype: IgG
• Clone: PSH06-46
• Conjugation: Biotin-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Positive Control: Recombinant standard Human Complement C5 protein (HA210636).
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH06-45] to Human Complement C5 antibody (Capture) (HA722682) and recombinant standard Human Complement C5 protein (HA210636) as the standard. The reference range value is 111-9,000pg/mll.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes