AB-680

AB-680

• CAS Number: 2105904-82-1
• UNSPSC Description: AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].
• Target Antigen: CD73
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/AB-680.html
• Purity: 99.71
• Solubility: DMSO : 200 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=P(CP(O)(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)C=C3N[C@H](C4=CC=CC=C4F)C)=C3C=N2)O1
• Molecular Weight: 580.82
• References & Citations: [1]Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: Phase 2