DCP-LA

• Description :

  DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca (2+) /calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].

• Product Name Alternative :

  FR236924

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; CaMK; Phosphatase; PKC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/DCP-LA.html

• Purity :

  98.00

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CCCCCCCC1C(CC2C(CCCCC)C2)C1

• Molecular Formula :

  C20H36O2

• Molecular Weight :

  308.50

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kanno T, et al. DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. Cell Physiol Biochem. 2015;37 (1) :193-200.|[2]Kanno T, et al. DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. J Cell Physiol. 2009 Oct;221 (1) :183-8. |[3]Yaguchi T, et al. Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation. Neurochem Res. 2010 May;35 (5) :712-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CaMK II; PKCε

• CAS Number :

  [28399-31-7]