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DCP-LA

CAT: 0804-HY-108599-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108599-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCĪµ. DCP-LA activates Ca (2+) /calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].
CAS Number
[28399-31-7]
Product Name Alternative
FR236924
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; CaMK; Phosphatase; PKC
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DCP-LA.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCCCCCCC1C(CC2C(CCCCC)C2)C1
Molecular Formula
C20H36O2
Molecular Weight
308.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Kanno T, et al. DCP-LA Activates Cytosolic PKCĪµ by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. Cell Physiol Biochem. 2015;37 (1) :193-200.|[2]Kanno T, et al. DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. J Cell Physiol. 2009 Oct;221 (1) :183-8. |[3]Yaguchi T, et al. Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation. Neurochem Res. 2010 May;35 (5) :712-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20Ā°C, 3 years; 4Ā°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK II; PKCĪµ

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