6-CEPN

CAT: 0804-HY-114569-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114569-01Size:5 mg
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Description
6-CEPN is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase) [1].
CAS Number
[1054549-73-3]
UNSPSC
12352005
Target
Autophagy; Cyclin G-associated Kinase (GAK) ; Ras
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6-cepn.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1CC(OC2=C1C(O)=C(C(O)=C2)/C=C/C3=CC=CC=C3)C4=CC=C(C=C4)O
Molecular Formula
C23H18O5
Molecular Weight
374.39
References & Citations
[1]Zhao Y, et al. 6-C- (E-phenylethenyl) naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR), 2016, 68 (Null) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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