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Cobicistat-d8

CAT: 0804-HY-10493SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10493SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat. Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC50 values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules[1][2][3].
CAS Number
2699607-48-0
Product Name Alternative
GS-9350-d8
UNSPSC
12352005
Target
Cytochrome P450; HIV; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
CN(CC1=CSC(C(C)C)=N1)C(N[C@H](C(N[C@H](CC[C@H](CC2=CC=CC=C2)NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4)=O)CCN5C([2H])(C([2H])(OC([2H])(C5([2H])[2H])[2H])[2H])[2H])=O
Molecular Formula
C40H45D8N7O5S2
Molecular Weight
784.07
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Temesgen Z. Cobicistat, a pharmacoenhancer for HIV treatments. Drugs Today (Barc) . 2013 Apr;49 (4) :233-7.|[3]Lianhong Xu, et al. Cobicistat (GS-9350) : A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer. ACS Med. Chem. Lett., 2010, 1 (5), pp 209–213
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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