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Olmesartan lactone impurity

CAT: 0804-HY-131276-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131276-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study[1][2].
CAS Number
849206-43-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/olmesartan-lactone-impurity.html
Purity
99.27
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1OC(C)(C)C2=C1N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(CCC)=N2
Molecular Formula
C24H24N6O2
Molecular Weight
428.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131 (3) :190-7.|[2]Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang (1-7) /Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67 (6) :503-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor

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