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Licofelone

CAT: 0804-HY-B1452-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1452-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2][3].
CAS Number
156897-06-2
Product Name Alternative
ML-3000
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Apoptosis; COX; Lipoxygenase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/licofelone.html
Purity
99.84
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)CC1=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)=C4N1CC(C)(C)C4
Molecular Formula
C23H22ClNO2
Molecular Weight
379.88
Precautions
H302, H319
References & Citations
[1]Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29 (2) :371-80.|[2]Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford) . 2004 Feb;43 Suppl 1:i21-5.|[3]Laufer SA, et al. (6,7-Diaryldihydropyrrolizin-5-yl) acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem. 1994 Jun 10;37 (12) :1894-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-LOX; COX

Alternative Products

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B1448-5Licofelone
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PXB42704-01Licofelone-d4
A11697-200Licofelone 200mg
A11697-100Licofelone 100mg
A11697-25Licofelone 25mg

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