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Licofelone (Standard)

CAT: 0804-HY-B1452R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1452R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Licofelone (Standard) is the analytical standard of Licofelone. This product is intended for research and analytical applications. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2][3].
CAS Number
156897-06-2
UNSPSC
12352100
Target
Apoptosis; COX; Lipoxygenase; Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(O)CC1=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)=C4N1CC(C)(C)C4
Molecular Formula
C23H22ClNO2
Molecular Weight
379.88
References & Citations
[1]Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29 (2) :371-80.|[2]Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford) . 2004 Feb;43 Suppl 1:i21-5.|[3]Laufer SA, et al. (6,7-Diaryldihydropyrrolizin-5-yl) acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem. 1994 Jun 10;37 (12) :1894-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
B1448-5Licofelone
A11697-50Licofelone 50mg
A11697-10Licofelone 10mg
C08299-5mgLicofelone (ML3000)
PXB42704-01Licofelone-d4
A11697-200Licofelone 200mg
A11697-100Licofelone 100mg
A11697-25Licofelone 25mg

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