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Shield-1

CAT: 0804-HY-112210-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-112210-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) [1][2][3].
CAS Number
914805-33-7
Product Name Alternative
Shld1
UNSPSC
12352005
Target
FKBP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/shield-1.html
Purity
99.73
Solubility
DMSO : 67.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5
Molecular Formula
C42H56N2O10
Molecular Weight
748.90
References & Citations
[1]Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296 (1) :F204-11.|[2]Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17 (1) :763-770.|[3]Laura A Banaszynski, et al. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell. 2006 Sep 8;126 (5) :995-1004.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12

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