Shield-1

• Description :

  Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) [1][2][3].

• Product Name Alternative :

  Shld1

• UNSPSC :

  12352005

• Target :

  FKBP

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/shield-1.html

• Purity :

  99.73

• Solubility :

  DMSO : 67.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5

• Molecular Formula :

  C42H56N2O10

• Molecular Weight :

  748.90

• References & Citations :

  [1]Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296 (1) :F204-11.|[2]Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17 (1) :763-770.|[3]Laura A Banaszynski, et al. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell. 2006 Sep 8;126 (5) :995-1004.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, stored under nitrogen

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  FKBP12

• CAS Number :

  [914805-33-7]