Shield-1

• UNSPSC Description:

  Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)[1][2][3].

• Target Antigen:

  FKBP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/shield-1.html

• Purity:

  99.73

• Solubility:

  DMSO : 67.5 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5

• Molecular Weight:

  748.90

• References & Citations:

  [1]Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11.|[2]Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17(1):763-770.|[3]Laura A Banaszynski, et al. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell. 2006 Sep 8;126(5):995-1004.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C, stored under nitrogen

• Clinical Information:

  No Development Reported

• CAS Number:

  914805-33-7