Shield-2

• Description:

  Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels[1][2].

• UNSPSC:

  12352005

• Target:

  FKBP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/shield-2.html

• Smiles:

  COC(C=C1CC[C@H](C2=CC(OCCN3CCOCC3)=CC=C2)OC([C@H]4N(CCCC4)C(NC(CC)CC)=O)=O)=C(C=C1)OC

• Molecular Formula:

  C35H51N3O7

• Molecular Weight:

  625.80

• References & Citations:

  [1]Grimley JS, et al. Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :759-61. |[2]Bonger KM, et al. Small-molecule displacement of a cryptic degron causes conditional protein degradation. Nat Chem Biol. 2011 Jul 3;7 (8) :531-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1013621-70-9