Shield-2

CAT: 0804-HY-113646Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-113646Size:1 Each
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AVAILABILITY: InStock
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Description
Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels[1][2].
CAS Number
[1013621-70-9]
UNSPSC
12352005
Target
FKBP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/shield-2.html
Smiles
COC(C=C1CC[C@H](C2=CC(OCCN3CCOCC3)=CC=C2)OC([C@H]4N(CCCC4)C(NC(CC)CC)=O)=O)=C(C=C1)OC
Molecular Formula
C35H51N3O7
Molecular Weight
625.80
References & Citations
[1]Grimley JS, et al. Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :759-61. |[2]Bonger KM, et al. Small-molecule displacement of a cryptic degron causes conditional protein degradation. Nat Chem Biol. 2011 Jul 3;7 (8) :531-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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