CCR2 antagonist 1

• UNSPSC Description:

  CCR2 antagonist 1 (compound 15a) is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].

• Target Antigen:

  CCR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/CCR2_antagonist_1.html

• Purity:

  98.00

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C([C@]1(C(C)C)C[C@H](N[C@@H]2CCC3=C2C=CC(Br)=C3)CC1)N4CC5=C(C=CC(C(F)(F)F)=C5)CC4

• Molecular Weight:

  549.47

• References & Citations:

  [1]Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1683534-96-4