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CCW 28-3

CAT: 0804-HY-156774Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156774Size:1 Each
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Description
CCW 28-3 is a PROTAC-based BRD4 degrader in a proteasome- and RNF4-dependent manner (Pink: JQ-1 (carboxylic acid) ; Black: linker (HY-170384) ; Blue: RNF4 ligand CCW16 (HY-143346) ).
CAS Number
2361142-23-4
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ccw-28-3.html
Smiles
O=C(CCl)N(C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)CC7=CC=CC=C7
Molecular Formula
C44H42Cl2N6O4S
Molecular Weight
821.81
References & Citations
[1]Carl C Ward, et al. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14 (11) :2430-2440.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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