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Pimecrolimus (hydrate)

CAT: 0804-HY-13723A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13723A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus[1][2][3].
CAS Number
1000802-56-1
Product Name Alternative
SDZ-ASM 981 (hydrate)
UNSPSC
12352211
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pimecrolimus-hydrate.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@@H](Cl)CC4)[C@H](C)[C@@H](O)CC3=O.[x].O
Molecular Formula
C43H68ClNO11.xH2O
References & Citations
[1]Grassberger M, et al. Pimecrolimus -- an anti-inflammatory drug targeting the skin. Exp Dermatol. 2004 Dec;13 (12) :721-30.|[2]Roman D, et al. Determination of the effect of calcineurin inhibitors on the rat's immune system after KLH immunisation. Toxicol Lett. 2004 Apr 1;149 (1-3) :133-40.|[3]Passeron T, et al. Treatment of oral erosive lichen planus with 1% pimecrolimus cream: a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. Arch Dermatol. 2007 Apr;143 (4) :472-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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