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Chlorotrianisene (Standard)

CAT: 0804-HY-B2158RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B2158RSize:1 Each
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Description
Chlorotrianisene (Standard) is the analytical standard of Chlorotrianisene. This product is intended for research and analytical applications. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].
CAS Number
569-57-3
UNSPSC
12352005
Target
COX; Estrogen Receptor/ERR; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/chlorotrianisene-standard.html
Smiles
Cl/C(C1=CC=C(OC)C=C1)=C(C2=CC=C(OC)C=C2)/C3=CC=C(OC)C=C3
Molecular Formula
C23H21ClO3
Molecular Weight
380.86
References & Citations
[1]Ruenitz PC, et al. Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells. J Steroid Biochem Mol Biol. 1997 Nov-Dec;63 (4-6) :203-9.|[2]Lounkine E, et al. Large-scale prediction and testing of drug activity on side-effect targets. Nature. 2012 Jun 10;486 (7403) :361-7.|[3]Kupfer D, et al. Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE) . Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261 (1) :59-62.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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B5912-5.1Chlorotrianisene
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A16446-100Chlorotrianisene 100mg
A16446-50Chlorotrianisene 50mg
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