Products for Research Use Only
RegisterLogin

MPI8

CAT: 0804-HY-158763Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-158763Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L) . This dual inhibition enhanced the overall antiviral potency and effect of MPI8. MPI8 can be used in clinical studies of COVID-19[1][2].
CAS Number
856242-63-2
Product Name Alternative
TG0205221
UNSPSC
12352005
Target
Cathepsin; SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mpi8.html
Smiles
O=C(N[C@H](C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC2CCCCC2)=O)[C@@H](C)OC(C)(C)C)OCC3=CC=CC=C3
Molecular Formula
C32H48N4O7
Molecular Weight
600.75
References & Citations
[1]Ma X R, et al. MPI8 is potent against SARS‐CoV‐2 by inhibiting dually and selectively the SARS‐CoV‐2 main protease and the host cathepsin L[J]. ChemMedChem, 2022, 17 (1) : e202100456.|[2]Yang S, et al. Synthesis, crystal structure, structure− activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor[J]. Journal of medicinal chemistry, 2006, 49 (16) : 4971-4980.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-12660-01MPI-0479605
HY-129715-01MPI-0441138
HY-P77089MPIF-1/CCL23, Human (His)
HY-P7765-01MPIF-1/CCL23, Human (75a.a)
HY-P72786-01MPIF-1/CCL23, Human (99a.a)
HY-P7259-01MPIF-1/CCL23, Human (99a.a, CHO)
HY-P7390MPIF/CCL23, 85a.a. (CHO-expressed), Human
HY-P77088MPIF-1/CCL23, Human (P.pastoris, His)
HY-P704795MPIF-1/CCL23, Human (99a.a, HEK293, His)
HY-RS23814Mpi Rat Pre-designed siRNA Set A

Alternative Products

CatalogName
T68541-01MPI8
GTR19275023-01MPI8 TFA

Popular Products