Acetaminophen-d7

Acetaminophen-d7

• CAS Number: 1219798-53-4
• UNSPSC Description: Acetaminophen-d7 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
• Target Antigen: COX; Endogenous Metabolite; Histone Acetyltransferase
• Type: Isotope-Labeled Compounds
• Related Pathways: Epigenetics;Immunology/Inflammation;Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Purity: 99.0
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: [2H]C([2H])([2H])C(NC1=C([2H])C([2H])=C(C([2H])=C1[2H])O)=O
• Molecular Weight: 158.21
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported