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Phoenixin-14 (TFA)

CAT: 0804-HY-P5762ASize: 1 EachDry Ice: NoHazardous: No
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Description
Phoenixin-14 (PNX-14) TFA, a neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH[1][2][3].
Product Name Alternative
PNX-14 (TFA)
UNSPSC
12352209
Target
GnRH Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/phoenixin-14-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N.O=C(C(F)(F)F)O.[x]
Molecular Formula
C75H110N18O20.xC2HF3O2
Molecular Weight
1583.78 (free base)
References & Citations
[1]Ma H, et al. Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia. Arch Biochem Biophys. 2020 Aug 15;689:108411.|[2]Rocca C, et al. Phoenixin-14: detection and novel physiological implications in cardiac modulation and cardioprotection. Cell Mol Life Sci. 2018 Feb;75 (4) :743-756.|[3]Jiang JH, et al. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015 Jun 1;286:39-48.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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