JC-171

CAT: 0804-HY-117432-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-117432-01Size:5 mg

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Description

JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1].

CAS Number

[2112809-98-8]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jc-171.html

Purity

98.41

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NCCC1=CC=C(S(=O)(NO)=O)C=C1)C2=CC(Cl)=CC=C2OC

Molecular Formula

C16H17ClN2O5S

Molecular Weight

384.83

References & Citations

[1]Chunqing Guo, et al. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2- (4-hydroxysulfamoyl-phenyl) -ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. ACS Chem Neurosci. 2017 Oct 18;8 (10) :2194-2201.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NLRP3

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