Recombinant Human CCL28

• Description:

  Recombinant human CCL28

• Product Name Alternative:

  rHuCCL28, MEC

• Gene Name:

  CCL28

• UniProt:

  Q9NRJ3

• Cellular Locus:

  Secreted.

• Reactivity:

  Human

• Target Antigen:

  C-C motif chemokine 28

• Target:

  CCL28

• Type:

  Protein

• Applications:

  Migration assay

• Dilution:

  Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

• Form:

  Lyophilized

• Function:

  Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

• Additionnal Information:

  Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in L1.2 cells expressing CCR10.

• Storage Conditions:

  12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.

• Specificity:

  CCL28

• Target Background:

  CCL28, also known as Mucosae-associated Epithelial Chemokine (MEC), is secreted by gastrointestinal and non-intestinal mucosal cells. It regulates chemotaxis of cells expressing surface receptors CCR3 and CCR10. This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury. CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland, salivary gland, intestine and other mucosal tissues. It has also been shown as a potential antimicrobial agent effective against certain pathogens, such as Gram negative and Gram positive bacteria and the fungus Candida albicans.

• CAS Number:

  9000-83-3