Recombinant Human CCL27

• Description:

  Recombinant human CCL27

• Product Name Alternative:

  rHuCCL27, CTACK

• Gene Name:

  CCL27

• UniProt:

  Q9Y4X3

• Cellular Locus:

  Secreted

• Reactivity:

  Human

• Target Antigen:

  C-C motif chemokine 27

• Target:

  CCL27

• Type:

  Protein

• Applications:

  Migration assay

• Dilution:

  Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

• Form:

  Lyophilized

• Function:

  Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

• Additionnal Information:

  Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in L1.2 cells expressing CCR10.

• Storage Conditions:

  12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.

• Specificity:

  CCL27

• Target Background:

  CCL27, also known as Cutaneous T-cell-attracting Chemokine (CTACK) is a ligand for cell surface receptor CCR10. It is responsible for chemotaxis of skin-homing memory T-cells during cutaneous inflammation. Interestingly, after CCR10-mediated internalization, CCL27, as well as a non-secreted splice variant of the same gene, can reach the nucleus and modulate transcription and cell behavior.

• CAS Number:

  9000-83-3