Recombinant Human CCL27

Recombinant Human CCL27

• Description: Recombinant human CCL27
• Product Name Alternative: rHuCCL27, CTACK
• CAS Number: 9000-83-3
• Gene Name: CCL27
• UniProt: Q9Y4X3
• Cellular Locus: Secreted
• Reactivity: Human
• Target Antigen: C-C motif chemokine 27
• Target: CCL27
• Type: Protein
• Applications: Migration assay
• Dilution: Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
• Form: Lyophilized
• Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.
• Additionnal Information: Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in L1.2 cells expressing CCR10.
• Storage Conditions: 12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.
• Specificity: CCL27
• Target Background: CCL27, also known as Cutaneous T-cell-attracting Chemokine (CTACK) is a ligand for cell surface receptor CCR10. It is responsible for chemotaxis of skin-homing memory T-cells during cutaneous inflammation. Interestingly, after CCR10-mediated internalization, CCL27, as well as a non-secreted splice variant of the same gene, can reach the nucleus and modulate transcription and cell behavior.