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Evans Blue

CAT: 0804-HY-B1102-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1102-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT) . Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability[1][2].
CAS Number
314-13-6
Product Name Alternative
Direct Blue 53; T-1824; C.I. 23860
UNSPSC
12352200
Hazard Statement
H350
Target
EAAT; iGluR
Type
Biochemical Assay Reagents
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Evans-Blue.html
Purity
99.86
Solubility
DMSO : ≥ 25 mg/mL|H2O : 31.25 mg/mL (ultrasonic)
Smiles
CC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(C)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5
Molecular Formula
C34H24N6Na4O14S4
Molecular Weight
960.81
Precautions
H350
References & Citations
[1]Anatol Manaenko, et al. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J Neurosci Methods. 2011 Feb 15;195 (2) :206-10. |[2]Linpeng Yao, et al. Evans Blue Dye: A Revisit of Its Applications in Biomedicine. Contrast Media Mol Imaging. 2018 Apr 22:2018:7628037.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Launched

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