Evans Blue

• Description:

  Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT) . Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability[1][2].

• Product Name Alternative:

  Direct Blue 53; T-1824; C.I. 23860

• UNSPSC:

  12352200

• Hazard Statement:

  H350

• Target:

  EAAT; iGluR

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Evans-Blue.html

• Purity:

  99.86

• Solubility:

  DMSO : ≥ 25 mg/mL|H2O : 31.25 mg/mL (ultrasonic)

• Smiles:

  CC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(C)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5

• Molecular Formula:

  C34H24N6Na4O14S4

• Molecular Weight:

  960.81

• Precautions:

  H350

• References & Citations:

  [1]Anatol Manaenko, et al. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J Neurosci Methods. 2011 Feb 15;195 (2) :206-10. |[2]Linpeng Yao, et al. Evans Blue Dye: A Revisit of Its Applications in Biomedicine. Contrast Media Mol Imaging. 2018 Apr 22:2018:7628037.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  Launched

• CAS Number:

  [314-13-6]