Coniferyl ferulate

• Description:

  Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC50 = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus[1][2][3][4][5].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bacterial; CaMK; Glutathione S-transferase; iGluR; p38 MAPK; P-glycoprotein; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/coniferyl-ferulate.html

• Purity:

  98.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(OC/C=C/C1=CC=C(O)C(OC)=C1)/C=C/C2=CC=C(O)C(OC)=C2

• Molecular Formula:

  C20H20O6

• Molecular Weight:

  356.37

• References & Citations:

  Angelicae sinensis

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  CaMK II; NMDA Receptor

• CAS Number:

  [63644-62-2]