Primaquine (diphosphate)

Primaquine (diphosphate)

• Product Name Alternative: Primaquine (phosphate); Primaquine (bisphosphate)
• CAS Number: 63-45-6
• UNSPSC Description: Primaquine diphosphate is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine diphosphate prevents relapse in vivax and ovale malaria[1].
• Target Antigen: Parasite
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/Primaquine-Diphosphate.html
• Purity: 99.61
• Solubility: DMSO : 250 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: CC(NC1=C2N=CC=CC2=CC(OC)=C1)CCCN.O=P(O)(O)O.O=P(O)(O)O
• Molecular Weight: 455.34
• References & Citations: [1]Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418.|[2]Qigui Li, et al. Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. Malar J. 2014 Apr 14:13:141. |[3]Ji-Hyang Kim, et al. Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation. Int J Mol Sci. 2021 Nov 30;22(23):12961. Advanced Therapeutics. 05 October 2021.|Ann Transl Med. 2021 Feb;9(3):194.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|ACS Omega. 2024 Feb 28;9(10):11870-11882.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched