Primaquine

CAT: 0804-HY-12651A-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12651A-01Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Primaquine is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine prevents relapse in vivax and ovale malaria[1][2].
CAS Number
[90-34-6]
UNSPSC
12352005
Hazard Statement
H301, H361
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/primaquine.html
Concentration
10mM
Purity
98.85
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC(NC1=C2N=CC=CC2=CC(OC)=C1)CCCN
Molecular Formula
C15H21N3O
Molecular Weight
259.35
Precautions
H301, H361
References & Citations
[1]Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418. |[2]Qigui Li, et al. Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. Malar J. 2014 Apr 14:13:141. |[3]Ji-Hyang Kim, et al. Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation. Int J Mol Sci. 2021 Nov 30;22 (23) :12961.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Plasmodium
Citation 01
ACS Omega. 2024 Feb 28;9 (10) :11870-11882.|Adv Sci (Weinh) . 2024 Nov 5:e2410285.|Adv Ther (Weinh) . 05 October 2021.|Ann Transl Med. 2021 Feb;9 (3) :194.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.

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