Primaquine

• Description :

  Primaquine is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine prevents relapse in vivax and ovale malaria[1][2].

• CAS Number :

  [90-34-6]

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H361

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/primaquine.html

• Concentration :

  10mM

• Purity :

  98.85

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  CC(NC1=C2N=CC=CC2=CC(OC)=C1)CCCN

• Molecular Formula :

  C15H21N3O

• Molecular Weight :

  259.35

• Precautions :

  H301, H361

• References & Citations :

  [1]Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418. |[2]Qigui Li, et al. Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. Malar J. 2014 Apr 14:13:141. |[3]Ji-Hyang Kim, et al. Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation. Int J Mol Sci. 2021 Nov 30;22 (23) :12961.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  Plasmodium

• Citation 01 :

  ACS Omega. 2024 Feb 28;9 (10) :11870-11882.|Adv Sci (Weinh) . 2024 Nov 5:e2410285.|Adv Ther (Weinh) . 05 October 2021.|Ann Transl Med. 2021 Feb;9 (3) :194.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.