CUDC-427

• Description :

  CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.

• Product Name Alternative :

  GDC-0917

• UNSPSC :

  12352005

• Target :

  IAP

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CUDC-427.html

• Purity :

  99.32

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)NC3=C(C4=CC=CC=C4)N=C(C5=NC=CO5)S3

• Molecular Formula :

  C29H36N6O4S

• Molecular Weight :

  564.70

• References & Citations :

  [1]Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41 (12) :2104-13.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1446182-94-0]