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Vismodegib-d7

CAT: 0804-HY-W716916-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W716916-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vismodegib-d7 is deuterium labeled Vismodegib. Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively[1][2].
CAS Number
2733145-73-6
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cancer
Smiles
ClC1=C(C([2H])=C(C([2H])=C1C2=C(C([2H])=C(C([2H])=N2)[2H])[2H])NC(C3=C(C=C(C=C3)S(C)(=O)=O)Cl)=O)[2H]
Molecular Formula
C19H7D7Cl2N2O3S
Molecular Weight
428.34
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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