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6-T-GDP

CAT: 0804-HY-134243Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134243Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation[1].
CAS Number
16541-19-8
Product Name Alternative
6-Thioguanosine 5'-diphosphate
UNSPSC
12352005
Target
Endogenous Metabolite; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/6-t-gdp.html
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O[C@H]1N(C=N2)C3=C2C(NC(N)=N3)=S
Molecular Formula
C10H15N5O10P2S
Molecular Weight
459.27
References & Citations
[1]Marinković, et al. Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug. The Journal of Immunology 192.9 (2014) : 4370-4378.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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