6-T-GDP

• Description :

  6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation[1].

• Product Name Alternative :

  6-Thioguanosine 5'-diphosphate

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite; Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/6-t-gdp.html

• Smiles :

  O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O[C@H]1N(C=N2)C3=C2C(NC(N)=N3)=S

• Molecular Formula :

  C10H15N5O10P2S

• Molecular Weight :

  459.27

• References & Citations :

  [1]Marinković, et al. Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug. The Journal of Immunology 192.9 (2014) : 4370-4378.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [16541-19-8]