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D-NMAPPD

CAT: 0804-HY-124962-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-124962-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-NMAPPD ((1R,2R) -B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs[1][2].
CAS Number
35922-06-6
Product Name Alternative
(1R,2R) -B13
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d-nmappd.html
Purity
99.74
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OC[C@H]([C@@H](C1=CC=C(C=C1)[N+]([O-])=O)O)NC(CCCCCCCCCCCCC)=O
Molecular Formula
C23H38N2O5
Molecular Weight
422.56
References & Citations
[1]Marie-Elaine Laurier-Laurin, et al.Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural Plast. 2014;2014:196812.|[2]M Selzner, et al.Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 2001 Feb 1;61 (3) :1233-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

D-Nmappd
CAS Number35922-06-6
PubChem CID10070893
IUPAC NameN-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]tetradecanamide
Molecular FormulaC23H38N2O5
Molecular Weight422.6
XLogP6.3
Topological Polar Surface Area115
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count16
Heavy Atom Count30
Formal Charge0
Complexity461
SMILES
CCCCCCCCCCCCCC(=O)N[C@H](CO)[C@@H](C1=CC=C(C=C1)[N+](=O)[O-])O
InChI
InChI=1S/C23H38N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-22(27)24-21(18-26)23(28)19-14-16-20(17-15-19)25(29)30/h14-17,21,23,26,28H,2-13,18H2,1H3,(H,24,27)/t21-,23-/m1/s1
InChIKey
XUSDVLHKNBOGJY-FYYLOGMGSA-N
Chemical Structure
2D Structure
2D structure of D-Nmappd
CAS: 35922-06-6
CID: 10070893
Formula: C23H38N2O5
MW: 422.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight422.6
XLogP36.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count16
Exact Mass422.27807232
Monoisotopic Mass422.27807232
Topological Polar Surface Area115 Ų
Heavy Atom Count30
Formal Charge0
Complexity461
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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