TAPI-1

TAPI-1

• CAS Number: 163847-77-6
• UNSPSC Description: TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins[1]. TAPI-1 is also a metalloproteinase (MMP) inhibitor[2].
• Target Antigen: MMP
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/TAPI-1.html
• Solubility: DMSO : 83.33 mg/mL (ultrasonic)
• Smiles: O=C(N[C@@H](CC1=CC=C2C=CC=CC2=C1)C(N[C@@H](C)C(NCCN)=O)=O)[C@H](CC(C)C)CC(NO)=O
• Molecular Weight: 499.60
• References & Citations: [1]Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2018 Mar;22(2):135-143.|[2]Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported