Canrenoate (potassium)

• UNSPSC Description:

  Canrenoate (Aldadiene) potassium, a proagent that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3].

• Target Antigen:

  Mineralocorticoid Receptor

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/canrenoate-potassium.html

• Purity:

  99.89

• Solubility:

  DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 100 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  C[C@@]12[C@@](CCC(O[K])=O)(O)CC[C@@]1([H])[C@]3([H])C=CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O

• Molecular Weight:

  396.56

• References & Citations:

  [1]Iqbal J, Andrew R, et al. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014;99(3):915-922.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  2181-04-6