Metoprolol-d6 (succinate)

• UNSPSC Description:

  Metoprolol-d6 (succinate) is deuterium labeled Metoprolol (succinate). Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].

• Target Antigen:

  Adrenergic Receptor; Apoptosis; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis;GPCR/G Protein;Neuronal Signaling;Others

• Field of Research:

  Cardiovascular Disease;Endocrinology;Cancer

• Smiles:

  OC(CNC(C([2H])([2H])[2H])C([2H])([2H])[2H])COC1=CC=C(CCOC)C=C1.O=C(O)CCC(O)=O

• Molecular Weight:

  391.49

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783.|[3]Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1;547(2):195-201.|[4]Hajatbeigi B, et al. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018; 10(4): 124-129.|[5]Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring;18(2):161-5.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported