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Metoprolol-d5

CAT: 0804-HY-17503S3Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17503S3Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Metoprolol-d5 is the deuterium labeled Metoprolol[1]. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[2][3][4].
CAS Number
959786-79-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Apoptosis
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Purity
96.93
Solubility
10 mM in DMSO
Smiles
CC(C)NC([2H])([2H])C(O)([2H])C([2H])([2H])OC1=CC=C(C=C1)CCOC
Molecular Formula
C15H20D5NO3
Molecular Weight
272.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783.|[3]Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1547 (2) :195-201.|[4]Hajatbeigi B, et al. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018 10 (4) : 124-129.|[5]Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring18 (2) :161-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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