CCL18 Rabbit pAb

CAT: 0855-ES17760-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES17760-01Size:50 µL

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Background

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

Description

This antimicrobial gene is one of several Cys-Cys (CC) Cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The Cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014],

Product Name Alternative

C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1; AMAC-1; CC chemokine PARC; Dendritic cell chemokine 1; DC-CK1; Macrophage inflammatory protein 4; MIP-4; Pulmonary and activation-regulated chemokine; Small-inducible cytokine A18) [Cleaved into: CCL18 (1-68) ; CCL18 (3-69) ; CCL18 (4-69) ]

UniProt

P55774

Swiss Prot

P55774

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human CCL18 AA range: 1-80

Target

CCL18

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; ELISA

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, ELISA (peptide) 1:5000-20000

Buffer

-20°C/1 year

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Secreted.

Other Product Names

Gene ID (Human)

6362

UniProtKB · P55774

C-C motif chemokine 18

CCL18_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P55774
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CCL18
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: B5BUM2, Q53X71

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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