Products for Research Use Only
RegisterLogin

Trifluridine

CAT: 0804-HY-A0061-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-A0061-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors[1][2][3][4].
CAS Number
70-00-8
Product Name Alternative
Trifluorothymidine; 5-Trifluorothymidine; TFT
UNSPSC
12352005
Hazard Statement
H341, H351, H361
Target
Apoptosis; Autophagy; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus; Thymidylate Synthase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Trifluorothymidine.html
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL|H2O : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1C[C@H](N2C(NC(C(C(F)(F)F)=C2)=O)=O)O[C@@H]1CO
Molecular Formula
C10H11F3N2O5
Molecular Weight
296.20
Precautions
H341, H351, H361
References & Citations
[1]Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340 (2) :457-62.|[2]Jia HJ, et al. Trifluridine induces HUVECs senescence by inhibiting mTOR-dependent autophagy. Biochem Biophys Res Commun. 2022 Jun 25;610:119-126.|[3]Suzuki N, et al. Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer. Oncol Lett. 2017 Jul;14 (1) :639-646.|[4]Li J, et al. Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer. Am J Cancer Res. 2020 Feb 1;10 (2) :507-522.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HSV-1; HSV-2

Related Products

CatalogName
HY-1544373’-β-Amino-2’,3’-dideoxy-5’-O-methoxy trityluridine

Alternative Products

CatalogName
BUP15738-01Trifluridine
A10948-100Trifluridine 100mg
RM-T043100-01Trifluorothymidine; Trifluridine
A10948-50Trifluridine 50mg
A10948-25Trifluridine 25mg
A10948-500Trifluridine 500mg
A10948-200Trifluridine 200mg
A10948-10Trifluridine 10mg
RG-A263192-01Trifluridine Impurity 22
RM-T041316-01Trifluridine Impurity 16

Popular Products